Regulation of hamster sperm hyperactivation by extracellular Na+
نویسندگان
چکیده
منابع مشابه
γ-Aminobutyric acid suppresses enhancement of hamster sperm hyperactivation by 5-hydroxytryptamine
Sperm hyperactivation is regulated by hormones present in the oviduct. In hamsters, 5-hydroxytryptamine (5HT) enhances hyperactivation associated with the 5HT2 receptor and 5HT4 receptor, while 17β-estradiol (E2) and γ-aminobutyric acid (GABA) suppress the association of the estrogen receptor and GABAA receptor, respectively. In the present study, we examined the regulatory interactions among 5...
متن کاملControl of hyperactivation in sperm.
BACKGROUND Sperm hyperactivation is critical to fertilization, because it is required for penetration of the zona pellucida. Hyperactivation may also facilitate release of sperm from the oviductal storage reservoir and may propel sperm through mucus in the oviductal lumen and the matrix of the cumulus oophorus. Hyperactivation is characterized by high amplitude, asymmetrical flagellar bending. ...
متن کاملEstrogen suppresses melatonin-enhanced hyperactivation of hamster spermatozoa
Hamster sperm hyperactivation is enhanced by progesterone, and this progesterone-enhanced hyperactivation is suppressed by 17β-estradiol (17βE2) and γ-aminobutyric acid (GABA). Although it has been indicated that melatonin also enhances hyperactivation, it is unknown whether melatonin-enhanced hyperactivation is also suppressed by 17βE2 and GABA. In the present study, melatonin-enhanced hyperac...
متن کاملIntracellular calcium increases with hyperactivation in intact, moving hamster sperm and oscillates with the flagellar beat cycle.
At some time before fertilization, mammalian sperm undergo a change in movement pattern, termed hyperactivation. There is evidence that hyperactivation offers an advantage to sperm for detaching from the oviductal mucosa, for penetrating viscoelastic substances in the oviduct, and for penetrating the zona pellucida. Hyperactivation is known to require extracellular calcium, but little else is k...
متن کاملMathematical modeling of calcium signaling during sperm hyperactivation.
Mammalian sperm must hyperactivate in order to fertilize oocytes. Hyperactivation is characterized by highly asymmetrical flagellar bending. It serves to move sperm out of the oviductal reservoir and to penetrate viscoelastic fluids, such as the cumulus matrix. It is absolutely required for sperm penetration of the oocyte zona pellucida. In order for sperm to hyperactivate, cytoplasmic Ca(2+) l...
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ژورنال
عنوان ژورنال: Reproduction
سال: 2016
ISSN: 1470-1626,1741-7899
DOI: 10.1530/rep-15-0367